Impact of cycling and walking on adiposity and healthcare costs among adults: longitudinal study / Impacto do ciclismo e da caminhada na adiposidade e nos custos de saúde em adultos: estudo longitudinal / Impacto de andar en bicicleta y caminar sobre la adiposidad y los costos de salud en adultos: estudio longitudinal

Abstract: Leisure-time physical activity seems relevant to prevent the development of chronic diseases and obesity. However, not much is known about the economic burden of these healthy behaviors, mainly in longitudinal designs. This study aimed to analyze the impact of walking and cycling on leisure-time on adiposity and healthcare costs among adults. This longitudinal study was conducted at a medium-size Brazilian city and included 198 participants with no missing data attended in the Brazilian Unified National Health System. Cycling and walking were assessed by a questionnaire with a face-to-face interview at four time-points (baseline, 6-month, 12-month, and 18-month). Healthcare costs were assessed using medical records. Adiposity markers included waist circumference and body fatness. Over the follow-up period, participants who were more engaged in cycling presented lower body fatness (p-value = 0.028) and healthcare costs (p-value = 0.038). However, in the multivariate model, the impact of cycling on costs was not significant (p-value = 0.507) due to the impact of number of chronic diseases (p-value = 0.001). Cycling on leisure-time is inversely related to adiposity in adults, whereas its role on preventing chronic diseases seems the main pathway linking it to cost mitigation.

Resumo: A atividade física no lazer parece relevante para prevenir o desenvolvimento de doenças crônicas e obesidade. No entanto, pouco se sabe sobre o impacto econômico destes comportamentos saudáveis, principalmente em estudos longitudinais. O objetivo deste estudo foi analisar o impacto da caminhada e do ciclismo como atividades de lazer na adiposidade e nos custos de saúde em adultos. Este estudo longitudinal foi realizado em uma cidade brasileira de médio porte e incluiu 198 participantes sem dados indisponíveis atendidos no Sistema Único de Saúde brasileiro. A caminhada e o ciclismo foram avaliados por meio de questionário e entrevista presencial em quatro momentos (linha de base, 6 meses, 12 meses e 18 meses). Os custos de saúde foram avaliados por meio de prontuários médicos. Os marcadores de adiposidade incluíram circunferência da cintura e gordura corporal. Durante o período de acompanhamento, os participantes que praticavam mais ciclismo apresentaram menos gordura corporal (p = 0,028) e custos de saúde (p = 0,038). Porém, no modelo multivariado, o impacto do ciclismo nos custos deixou de ser significativo (p = 0,507) devido ao impacto do número de doenças crônicas (p = 0,001). O ciclismo no momento de lazer está inversamente relacionado à adiposidade em adultos, enquanto o seu papel na prevenção de doenças crônicas parece ser o principal aspecto que o liga à redução de custos.

Resumen: La actividad física en el ocio parece relevante para prevenir el desarrollo de enfermedades crónicas y la obesidad. Sin embargo, poco se sabe sobre el impacto económico de estos comportamientos saludables, especialmente en estudios longitudinales. El objetivo de este estudio fue analizar el impacto de caminar y andar en bicicleta como actividades de ocio sobre la adiposidad y los costos de salud en adultos. Este estudio longitudinal se llevó a cabo en una ciudad brasileña de tamaño mediano e incluyó a 198 participantes sin datos indisponibles atendidos en el Sistema Único de Salud brasileño. Se evaluaron los hábitos de caminar y andar en bicicleta mediante un cuestionario y una entrevista cara a cara en cuatro momentos (inicial, 6 meses, 12 meses y 18 meses). Los costos de atención médica se evaluaron utilizando registros médicos. Los marcadores de adiposidad incluyeron la circunferencia de la cintura y la grasa corporal. Durante el período de seguimiento, los participantes que practicaban más ciclismo presentaron menos grasa corporal (p = 0,028) y costos de salud (p = 0,038). Sin embargo, en el modelo multivariado, el impacto del ciclismo en los costos dejó de ser significativo (p = 0,507) debido al impacto del número de enfermedades crónicas (p = 0,001). El hábito de andar en bicicleta en los momentos de ocio está inversamente relacionado con la adiposidad en los adultos, mientras que su papel en la prevención de enfermedades crónicas parece ser el principal aspecto que lo vincula con la reducción de costos.

Sedentary behavior, abdominal obesity and healthcare costs in Brazilian adults with cardiovascular diseases: a cross-sectional study

ABSTRACT BACKGROUND: Research on the economic burden of sedentary behavior and abdominal obesity on health expenses associated with cardiovascular diseases is scarce. OBJECTIVE: The objective of this study was to verify whether sedentary behavior, isolated and combined with abdominal obesity, influences the medication expenditure among adults with cardiovascular diseases. DESIGN AND SETTING: This cross-sectional study was conducted in the city of President Prudente, State of São Paulo, Brazil in 2018. METHODS: The study included adults with cardiovascular diseases, aged 30-65 years, who were treated by the Brazilian National Health Services. Sedentary behavior was assessed using a questionnaire. Abdominal obesity was defined by waist circumference. Medication expenditures were verified using the medical records of each patient. RESULTS: The study included a total of 307 adults. Individuals classified in the group with risk factor obesity combined (median [IQ] USD$ 29.39 [45.77]) or isolated (median [IQ] USD$ 27.17 [59.76]) to sedentary behavior had higher medication expenditures than those belonging to the non-obese with low sedentary behavior group (median [IQ] USD$ 13.51 [31.42]) (P = 0.01). The group with combined obesity and sedentary behavior was 2.4 (95%CI = 1.00; 5.79) times more likely to be hypertensive. CONCLUSION: Abdominal obesity was a determining factor for medication expenses, regardless of sedentary behavior, among adults with cardiovascular diseases.

Cost-utility analysis of traditional drug therapy with and without exercise program for hypertensive patients in real-life data primary health care

Abstract Aim: The study aimed to conduct a cost-utility analysis of traditional drug therapy (TDT) provided for hypertensive patients at primary care in comparison to the protocol based on combination with an exercise program (TDT+E) in real-life conditions, adopting a health system perspective. Methods: Longitudinal study based on enrollment of 49 hypertensive adults distributed into two groups, for 12 months. Quality-adjusted life years were estimated using health-related quality of life. Direct health care costs were calculated including inputs and human resources in primary care from medical records. Sensitivity analysis was performed based on multivariate and probabilistic scenarios. Results: Incremental cost-effectiveness ratios of TDT+E in comparison to TDT were +79.69. Sensitivity analysis showed that TDT+E presented advantages considering uncertainties. Conclusion: Our findings show that exercise programs may improve quality of life and life expectancy among hypertensive patients.

Sleep pattern, obesity and healthcare expenditures in Brazilian adults / Padrões do sono, obesidade e despesas em saúde com brasileiros adultos

Abstract The aim of this study was to analyze the relationship between sleep pattern and healthcare expenditures in adults, as well as to identify whether physical activity, biochemical markers and obesity affect this relationship. The sample was composed of 168 adults aged ≥ 50 years attended by two Basic Healthcare Units in Presidente Prudente, SP, Brazil. Health expenditure, sleep pattern, anthropometry, adiposity index, physical activity, metabolic and cardiovascular variables were assessed. Statistical analyses were performed using Kruskal-Wallis, Mann-Whitney and Spearman tests. Sleep disorders were positively correlated to higher costs with medicines and negatively correlated to costs with laboratory tests, even after adjusts by confounders. In addition, healthcare costs were also correlated to physical activity score, blood pressure, obesity and metabolic variables. Severe sleep disorders and high percentage of body fat were associated with increased use of medications. Sleep pattern is correlated to primary care healthcare costs, obesity and physical activity level.

Resumo O objetivo deste estudo foi analisar a relação entre padrão de sono e despesas de saúde em adultos, bem como identificar se atividade física, marcadores bioquímicos e obesidade afetam esse relacionamento. A amostra foi composta por 168 adultos com idade ≥ 50 anos atendidos por duas unidades básicas de saúde em Presidente Prudente, SP, Brasil. Foram avaliadas as despesas de saúde, padrões do sono, antropometria, atividade física, variáveis metabólicas e cardiovasculares. Foram utilizados Kruskal-Wallis, Mann-Whitney e Spearman. Os distúrbios do sono foram correlacionados positivamente com os custos mais elevados com medicamentos e negativamente com os custos com testes laboratoriais, mesmo após ajuste por fatores de confusão. Além disso, os custos de saúde também foram correlacionados ao escore de atividade física, pressão arterial, obesidade e variáveis metabólicas. Distúrbios graves do sono e alta porcentagem de gordura corporal foram associados ao aumento do uso de medicamentos. O padrão de sono está correlacionado com os custos de cuidados de saúde primários, obesidade e atividade física.

Associação entre qualidade do sono e doenças cardiometabólicas de pacientes da Atenção Primária à Saúde / Association between sleep quality and cardiometabolic diseases of primary care system patients

A privação do sono está relacionada ao desenvolvimento de doenças cardiometabólicas. O objetivo deste estudo foi analisar a associação entre qualidade do sono e ocorrência de doenças cardiometabólicas em adultos atendidos na Atenção Primária à Saúde. Estudo longitudinal composto por 169 adultos (68,6% do sexo feminino), média de idade 61,80 (desvio padrão = 8,80), acompanhados por 30 meses. A presença das doenças hipertensão arterial, dislipidemia, diabetes mellitus e ocorrência de infarto e a qualidade do sono foram mensuradas por meio de questionários. Os participantes foram divididos em grupos de acordo com a qualidade do sono (adequada/inadequada). Para verificar a diferença de idade, classe econômica, atividade física habitual e circunferência de cintura, entre os grupos a e b, utilizou-se o teste t de Student para amostras independentes. Para comparar a proporção das doenças (hipertensão arterial, infarto, diabetes e dislipidemias) entre os grupos, utilizou-se o teste Qui-quadrado com correção de Yates. A regressão logística binária foi utilizada para testar a magnitude de tais associações, ajustadas por sexo, idade, atividade física, obesidade abdominal, etilismo e tabagismo. As análises estatísticas foram realizadas no software BioEstat (versão 5.0) e o nível de significância adotado foi de p < 0,05. Verificou-se que 83,4% dos adultos reportaram ao menos uma alteração na qualidade do sono e os que apresentaram inadequada qualidade do sono tiveram 3,4 vezes mais chances de reportar diabetes (OR = 3,47; IC95%: 1,06-11,30), comparados aos com o sono adequado. Inadequada qualidade do sono parece contribuir para o aumento da ocorrência de diabetes mellitus, independente do tempo de prática de atividade física e a obesidade abdominal

Sleep deprivation is related to the development of cardiometabolic diseases. The aim of this study was to analyze the association between sleep quality and occurrence of cardiometabolic diseases in adults attending Primary Health Care. Longitudinal study of 169 adults (68.6% female), mean age 61.80 (deviation = 8.80), followed for 30 months. The presence of the diseases hypertension, dyslipidemia, diabetes mellitus and occurrence of infarction and the quality of sleep were measured using questionnaires. Participants were divided into groups according to sleep quality (adequate / inadequate). To verify the difference in age, economic class, habitual physical activity and waist circumference, between groups a and b, the Student's t test for in-dependent samples was used. To compare the proportion of diseases (hypertension, heart attack, diabetes, and dyslipidemia) between the groups, the chi-square test with Yates correction was used. Binary logistic regression was used to test the magnitude of such associations, adjusted for gender, age, physical activity, abdominal obesity, alcoholism and smoking. Statistical analyzes were performed using BioEstat software (version 5.0) and the significance level adopted was p <0.05. 83.4% of adults reported at least one change in sleep quality and those with inadequate sleep quality were 3.4 times more likely to report diabetes (OR = 3.47; 95%CI: 1.06 -11.30) compared to those with adequate sleep. Inadequate sleep quality seems to contribute to the increased occurrence of diabetes mellitus, regardless of the length of physical activity and abdominal obesity

Type 2 diabetes, healthcare expenditures and its correlation with anthropometric factors and physical activity: 18-month follow-up in a Brazilian city

AIMS: To compare the profile of adults attended at primary care level of the Brazilian National Health System according to occurrence of T2DM during 18 months of follow-up. METHOD: Longitudinal study carried out with 316 adults. T2DM and PA were assessed by questionnaires. Measurements of weight, height and waist circumference (WC) were also performed. Healthcare expenditures were based on the demand of services registered in medical records. Analysis of variance (ANOVA) with Tukey's post hoc test was used, as well as their similar for non-parametric variables. Spearman's correlation coefficient analyzed the relationship between variables. All analyzes were performed using the statistical software BioEstat (release 5.0) and the significance level was set at p-value <0.05. RESULTS: Patients with T2DM at baseline showed higher values of WC, BMI, nursing appointments, customer services, medication, total cost and lower values of PA when compared to patients T2DM-free. Patients who developed T2DM during the follow-up presented higher values of WC, screening, pharmacy frequency, medications and total cost when compared to individuals without T2DM. Being in the highest quartile of PA did not change the costs of health services among patients T2DM-free. Healthcare expenditures were positively correlated to BMI among participants T2DM-free and with T2DM at baseline. CONCLUSION: Participants with T2DM and participants who developed T2DM during the follow-up showed higher values of BMI, WC, healthcare expenditures and were less active when compared to participants T2DM-free. Healthcare expenditures were positively correlated with BMI among participants with T2DM at baseline and T2DM-free.(AU)

Association of insufficient physical activity with sarcopenia and sarcopenic obesity in individuals aged 50 years or more / Análise da associação da prática insuficiente de atividade física com sarcopenia e obesidade sarcopênica em indivíduos com idade igual ou superior a 50 anos

ABSTRACT Objective: To analyze the association of insufficient physical activity in different domains with sarcopenia or sarcopenic obesity in patients aged ³50 years. Methods: The sample consisted of 770 males and females. Sarcopenia was diagnosed when the individual had: (1) low muscle mass and muscle strength; or (2) low walking speed and low muscle mass; sarcopenic obesity was diagnosed when individuals were at risk of obesity and sarcopenia. Muscle mass was given by a predictive equation, and then the muscle mass index (in kg/m²) was given by muscle mass divided by height squared. Muscle strength, in kg, was given by measuring handgrip strength with a digital dynamometer. The 4m walk test evaluated walking sped. Low muscle mass, muscle strength, and walking speed were defined as the respective values below the 25th percentile, and risk of obesity was defined as body mass index ³25kg/m2. Results: Habitual physical activity was investigated by a questionnaire. Insufficient leisure-time physical activity was associated with sarcopenia (OR=2.55; 95%CI=1.10-5.88). In addition, insufficient leisure-time physical activity (OR=4.75; 95%CI=1.64-13.72), leisure-time and commuting physical activities (OR=2.49; 95%CI=1.02-6.11, and habitual physical activity (OR=3.55; 95%CI=1.0-11.79) were associated with sarcopenic obesity. Conclusion: Insufficient physical activity is associated with sarcopenia or sarcopenic obesity in the study individuals aged ³50years.

RESUMO Objetivo: Analisar a associação entre a prática insuficiente de atividade física em diferentes domínios e a presença de sarcopenia ou obesidade sarcopênica em indivíduos com idade maior ou igual a 50 anos. Métodos: A amostra foi constituída por 770 indivíduos de ambos os sexos. Para o diagnóstico da sarcopenia, considerou--se: (1) baixas massa e força muscular; ou (2) baixa velocidade de locomoção e baixa massa muscular; para o diagnóstico de obesidade sarcopênica, foram considerados aqueles com indicativo de risco para obesidade e sarcopenia. A massa muscular foi mensurada por meio de equação preditiva e, posteriormente, foi calculado o índice de massa muscular em kg/m² a partir da razão entre massa muscular e estatura. A força muscular foi estimada, em kg, por força de preensão manual através de um dinamômetro digital. O teste de caminhada de quatro metros foi utilizado para avaliar a velocidade de locomoção. Foram considerados com baixas massa muscular, força muscular e velocidade de locomoção os indivíduos com valores abaixo do percentil 25; já os indivíduos com indicativo de risco para obesidade foram aqueles com valores de índice de massa corporal igual ou superior a 25kg/m2. A prática de atividade física habitual foi avaliada por questionário autorreferido. Resultados: A prática insuficiente de exercício físico no lazer associou-se à sarcopenic (OR=2,55; IC95%=1,10-5,88). Além disso, a prática insuficiente de exercício físico no lazer (OR=4,75; IC95%=1,64-13,72) e atividade física no lazer e locomoção (OR=2,49; IC95%=1,02-6,11), bem como a atividade física habitual (OR=3,55; IC95%=1,07-11,79) se associaram à obesidade sarcopênica. Conclusão: A prática insuficiente de atividade física associou-se à sarcopenia ou à obesidade sarcopênica em indivíduos com idade maior ou igual a 50 anos na amostra investigada.

Association between osteoporosis, health-related productivity loss and use of hospital services in outpatients of the Brazilian National Health System

Aims: To analyze factors associated with osteoporosis among outpatients of the Brazilian National Health System and to identify their association with hospital and labor economic outcomes. Methods: Cross-sectional study carried out in the city of Presidente Prudente / SP. The sample consisted of 542 adults of both sexes and aged ≥ 50 years old. The occurrence of osteoporosis, health-related productivity loss, use of hospital services and level of physical activity were assessed using questionnaires. Statistical analysis was composed of chi-square test, binary logistic regression and Mann-Whitney test. The significance level adopted was p-value <0.05. Results: The prevalence of osteoporosis was 14.4% (95% CI: 11.4% - 17.3%) and it was associated with female sex (p = 0.001), lower economic status (p-value = 0.036) and obesity (p-value = 0.003). Participants with osteoporosis showed a higher incidence of surgery in the last 12 months (OR = 2.13 [1.04 to 4.35]), productivity loss (OR = 1.91 [1.13 to 3.42]) and disability retirement (OR = 2.03 [1.20 to 3.43]). Over the past 12 months, the sum of direct and indirect economic loss was R$ 1,382,630.00. Conclusion: The female sex, lower economic status and obesity were associated with a higher occurrence of osteoporosis, and consequent higher use of hospital services and significant economic losses.(AU)

Association between sleep disorders and chronic diseases in patients of the brazilian national health system / Associação entre distúrbios do sono e doenças crônicas em pacientes do sistema único de saúde

ABSTRACT Many factors are associated with sleep disorders, causing an increase in health spending. The objective of this study was to analyze the association of sleep disorders and non-communicablechronic diseases in patients over 50 years of age, attended by Basic Health Care Units of Presidente Prudente. In total, 363 patients participated. The history of diseases was self-reported through the use of a questionnaire, the level of physical activity was evaluated by the Baecke questionnaire, and sleep quality was assessed using the Mini-Sleep Questionnaire. Anthropometric and body composition data were collected using a stadiometer and scale; patients in the highest (75th) percentile were considered obese. Statistical analysis was performed using the Student t test, chi-square test, and binary logistic regression. The results showed that sleep disorders are associated with osteoporosis, arthritis/osteoarthritis, low back pain, depression, and obesity. Additionally, obesity and physical inactivity influence the occurrence of non-communicable chronic diseases.

RESUMO Inúmeros fatores estão associados aos distúrbios do sono ocasionando o aumento nos gastos com saúde. O objetivo do trabalho foi analisar a associação dos distúrbios do sono e doenças crônicas não transmissíveis em pacientes com idade superior a 50 anos atendidos por Unidades Básicas de Saúde de Presidente Prudente. Participaram 363 pacientes. O histórico de doenças foi auto relatada a partir da aplicação de questionário, o nível de atividade física foi verificado através do questionário de Baecke, e a qualidade do sono foi avaliada utilizando o Mini-Sleep questionnaire. Dados antropométricos e de composição corporal foram coletados utilizando estadiômetro e balança, foram considerados obesos os pacientes dentro do percentil 75. A análise estatística foi composta pelos testes t de Student, qui-quadrado, e regressão logística binária. Os resultados mostraram que o distúrbio do sono está associado as doenças osteoporose, artrite/artrose, dor lombar, depressão e obesidade. Adicionalmente obesidade e inatividade física influenciam na ocorrência de doenças crônicas não transmissíveis.

Distúrbios do sono em adultos de uma cidade do Estado de São Paulo / Sleep disturbances in adults in a city of Sao Paulo state

OBJETIVO: Analisar a ocorrência de distúrbios relacionados ao sono entre adultos de Presidente Prudente, São Paulo, bem como identificar suas associações com variáveis comportamentais, sociodemográficas e de estado nutricional. MÉTODOS: Após a seleção aleatória da amostra, foram realizadas entrevistas face a face com 743 adultos de ambos os sexos, residentes na cidade de Presidente Prudente, São Paulo. Foram aplicados questionários para análise de distúrbios relacionados ao sono, variáveis sociodemográficas (sexo, idade, etnia, escolaridade), comportamentais (atividade física no lazer, etilismo e tabagismo) e de estado nutricional. RESULTADOS: Foram observados distúrbios relacionados ao sono em 46,7% da amostra, com intervalo de confiança de 95% (IC95%) 43,1 - 50,2. Após a análise multivariada, foi observado que o sexo feminino, com odds ratio (OR) = 1,74 (IC95% 1,26 - 2,40), escolaridade (OR = 0,49; IC95% 0,28 - 0,82), sobrepeso (OR = 1,99; IC95% 1,39 - 2,85) e obesidade (OR = 2,90; IC95% 1,94 - 4,35) foram associados à ocorrência de distúrbios relacionados ao sono. CONCLUSÃO: É elevada a ocorrência de distúrbios de sono na amostra analisada, os quais foram mais frequentes em mulheres, pessoas de menor escolaridade e com sobrepeso e obesidade. .

OBJECTIVE: To analyze the occurrence of sleep-related disorders among adults from Presidente Prudente, Brazil, as well as to identify associations with behavioral, socio-demographic and nutritional status variables. METHODS: After random selection of the sample, interviews were performed with 743 adults of both genders, living in Presidente Prudente, Brazil. Sleep-related disorders, demographic variables (sex, age, ethnicity and schooling), behavioral variables (leisure physical activity, alcohol consumption, and smoking) and nutritional status were analyzed by questionnaires. RESULTS: The prevalence of sleep-related disorders was 46.7%, with 95% confidence interval (95%CI) 43.1 - 50.2. In the multivariate analysis, female sex, with odds ratio (OR) 1.74 (95%CI 1.26 - 2.40), schooling (OR = 0.49; 95%CI 0.28 - 0.82), overweight (OR = 1.99; 95%CI 1.39 - 2.85) and obesity (OR = 2.90; 95%CI 1.94 - 4.35) were associated with sleep-related disorders. CONCLUSION: There is high occurrence of sleep-related disorders in this sample, which was associated with female sex, lower schooling, overweight and obesity. .